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Certain medications such as birth control pills, chemotherapy drugs, and antibiotics can cause pigmentation

The Fe(II) site was, however, well-defined by the data, revealing an octahedral Fe(II) coordination site, with three protein-derived ligands, H56, H119, and D145, arranged as a facial triad on one side of the Fe(II), and three open coordination sites modeled with high occupancy water molecules (Fig